BDBM367848 3-(3-aminoisoquinolin-8- yl)-6-(azetidin-3- ylsulfonyl)-2-(2H-tetrazol- 5-yl)benzenesulfonamide::US10227331, Example 35

SMILES Nc1cc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(=O)(=O)C3CNC3)c2cn1

InChI Key InChIKey=BLXZAIBKQOYUSB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367848   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367848(US10227331, Example 35 | 3-(3-aminoisoquinolin-8- ...)
Affinity DataIC50: 0.503nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367848(US10227331, Example 35 | 3-(3-aminoisoquinolin-8- ...)
Affinity DataIC50: 0.0700nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367848(US10227331, Example 35 | 3-(3-aminoisoquinolin-8- ...)
Affinity DataIC50: 0.243nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent