BDBM367630 N-((1R,2R)-3-(azetidin-1-yl)-1-(4- cyclopropoxy-3-fluorophenyl)-1- hydroxypropan-2-yl)-7-chloro-1H- benzo[4,5]thieno[2,3-d][1,2]oxazine- 4-carboxamide::US10227312, Example 15::US10759769, Example 15

SMILES O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NOCc2c1sc1cc(Cl)ccc21)c1ccc(OC2CC2)c(F)c1

InChI Key InChIKey=TXAGIPHWNXGVRZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367630   

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367630(US10227312, Example 15 | N-((1R,2R)-3-(azetidin-1-...)
Affinity DataIC50: 550nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367630(US10227312, Example 15 | N-((1R,2R)-3-(azetidin-1-...)
Affinity DataIC50: 550nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent