BDBM367207 6-(4-fluorophenyl)-2-oxo-N- (4-phenylbutyl)-1,3- benzoxazole-3-carboxamide::US10226452, Example 25

SMILES Fc1ccc(cc1)-c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1

InChI Key InChIKey=DPYVAZSLMQCVOG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 367207   

TargetAcid ceramidase(Human)
University of California

US Patent
LigandPNGBDBM367207(6-(4-fluorophenyl)-2-oxo-N- (4-phenylbutyl)-1,3- b...)
Affinity DataIC50: 79nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetAcid ceramidase(Human)
University of California

US Patent
LigandPNGBDBM367207(6-(4-fluorophenyl)-2-oxo-N- (4-phenylbutyl)-1,3- b...)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
University of California

US Patent
LigandPNGBDBM367207(6-(4-fluorophenyl)-2-oxo-N- (4-phenylbutyl)-1,3- b...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells preincubated for 30 mins followed by fluorogenic probe addition and measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
University of California

US Patent
LigandPNGBDBM367207(6-(4-fluorophenyl)-2-oxo-N- (4-phenylbutyl)-1,3- b...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed