BDBM365744 US9867826, Compound 43::cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(2-trifluoromethyl-pyridin-4-yl)-1H-imidazol-2-yl]-3-fluoro-piperidin-1-yl}-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

SMILES F[C@H]1CN(CC[C@H]1c1nc(cn1CCN1CCC1)-c1ccnc(c1)C(F)(F)F)c1ncnc2[nH]cc(C#N)c12

InChI Key InChIKey=AVMOOTKRYPDMNB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 365744   

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM365744(cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(2-trifluoromet...)
Affinity DataIC50: 5.5nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Patent

US Patent
LigandPNGBDBM365744(cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(2-trifluoromet...)
Affinity DataIC50: 5.5nMAssay Description:AKT: A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent