BDBM365367 US10633373, Example 72::US10669265, Example 72::US9868726, Example 72::dimethyl 5,5'[N-({6-amino-5- [4-({[3- (trifluoromethyl)phenyl]carbamoyl} amino)phenyl]pyridin-3- yl}carbonyl)sulfonimidoyl] dipentanoate

SMILES COC(=O)CCCCS(=O)(CCCCC(=O)OC)=NC(=O)c1cnc(N)c(c1)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1

InChI Key InChIKey=QLCHTTFSIBNNDD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 365367   

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365367(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Affinity DataIC50: 42nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365367(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Affinity DataIC50: 13nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365367(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Affinity DataIC50: 42nMAssay Description:VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365367(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Affinity DataIC50: 13nMAssay Description:PDGFRβ: Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365367(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Affinity DataIC50: 42nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365367(US9868726, Example 72 | dimethyl 5,5'[N-({6-amino-...)
Affinity DataIC50: 13nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent