BDBM365350 US10633373, Example 55::US10669265, Example 55::US9868726, Example 55::methyl 5-[N-({6-amino-5-[5- ({[(3-chloro-4- fluorophenyl)amino]carbonyl} amino)-1-benzothien-2- yl]pyridin-3-yl}carbonyl)-S- methylsulfonimidoyl]pentanoate

SMILES COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(F)c(Cl)c3)ccc2s1

InChI Key InChIKey=PCPXTLXXRRQODN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365350   

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365350(US9868726, Example 55 | methyl 5-[N-({6-amino-5-[5...)
Affinity DataIC50: 4nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365350(US9868726, Example 55 | methyl 5-[N-({6-amino-5-[5...)
Affinity DataIC50: 4nMAssay Description:VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365350(US9868726, Example 55 | methyl 5-[N-({6-amino-5-[5...)
Affinity DataIC50: 4nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent