BDBM365254 1-{3-[2-(3,3-Difluoro- pyrrolidin-1-yl)-6-(4- trifluoromethyl-pyridin-2- ylamino)-pyrimidin-4-yl]- piperidin-1-yl}-2,2-difluoro- ethanone::US9868720, No. 178

SMILES FC(F)C(=O)N1CCCC(C1)c1cc(Nc2cc(ccn2)C(F)(F)F)nc(n1)N1CCC(F)(F)C1

InChI Key InChIKey=NZEZJWHXHNIGIN-UHFFFAOYSA-N

Data  1 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365254   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Genentech

US Patent

LigandBDBM365254(US9868720, No. 178 | 1-{3-[2-(3,3-Difluoro- pyrrol...)Copy SMILESCopy InChI

Affinity DataKi:  26.8nMAssay Description:DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details
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