BDBM36511 5-((2-Carboxy-1H-benzo[g]indol-1-yl)methyl)isoxazole-3-carboxylic acid, 12::CID46398842

SMILES OC(=O)c1cc(Cn2c(cc3ccc4ccccc4c23)C(O)=O)on1

InChI Key InChIKey=IWARKPAWPYGVBI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 36511   

TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36511(CID46398842 | 5-((2-Carboxy-1H-benzo[g]indol-1-yl)...)
Affinity DataIC50: 80nMpH: 7.4 T: 2°CAssay Description:A biophysical assay using NMR spectroscopy to identify fragments with higher binding affinity to human recombinant FPPS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36511(CID46398842 | 5-((2-Carboxy-1H-benzo[g]indol-1-yl)...)
Affinity DataIC50: 80nMAssay Description:Inhibition of FPPS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36511(CID46398842 | 5-((2-Carboxy-1H-benzo[g]indol-1-yl)...)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N- terminal His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed