BDBM364589 US9862730, Example 41
SMILES Cc1nn2cc(nc2s1)-c1cc2ccccc2o1
InChI Key InChIKey=RAMARXZSROCBOX-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 364589
Affinity DataIC50: 18.6nMAssay Description:The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair