BDBM364565 6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazole::US9862730, Example 1

SMILES CSc1nn2cc(nc2s1)-c1cc2ccccc2o1

InChI Key InChIKey=RRXRVGBFTJMNCG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 364565   

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM364565(US9862730, Example 1 | 6-(Benzofuran-2-yl)-2-(meth...)
Affinity DataIC50: 14nMAssay Description:The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM364565(US9862730, Example 1 | 6-(Benzofuran-2-yl)-2-(meth...)
Affinity DataIC50: 270nMAssay Description:Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM364565(US9862730, Example 1 | 6-(Benzofuran-2-yl)-2-(meth...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM364565(US9862730, Example 1 | 6-(Benzofuran-2-yl)-2-(meth...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human PAR4 expressed in HEK293 cells assessed as Ala-(L-4-F-Phe)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-induced inhibition of calcium mobiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM364565(US9862730, Example 1 | 6-(Benzofuran-2-yl)-2-(meth...)
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at PAR4 in human platelet-rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM364565(US9862730, Example 1 | 6-(Benzofuran-2-yl)-2-(meth...)
Affinity DataIC50: 940nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed