BDBM364533 Trans N-(4-Hydroxycyclohexyl)-4-methyl-3-(6-(2-methylthiazol-5-yl)pyrazin-2-yl)benzenesulfonamide::US9862711, Example 5

SMILES Cc1ncc(s1)-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1

InChI Key InChIKey=MUNKBGMFHWUNDV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 364533   

LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 15nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, US...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 90nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 150nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 1.12E+3nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, US...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 1.81E+3nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 4.77E+3nMAssay Description:mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM364533(US9862711, Example 5 | Trans N-(4-Hydroxycyclohexy...)
Affinity DataIC50: 9.10E+3nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent