BDBM364532 Trans 3-[6-(1,3-Dimethyl-1H-pyrazol-4-yl)-pyrazin-2-yl]-4-methyl-N-(3-methyl-oxetan-3-ylmethyl)-benzenesulfonamide::US9862711, Example 4

SMILES Cc1nn(C)cc1-c1cncc(n1)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1

InChI Key InChIKey=OJHSROFLMBEBRH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 364532   

LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 14nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, US...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 60nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 70nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 680nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, US...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 890nMAssay Description:mTOR: Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 4.30E+3nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM364532(US9862711, Example 4 | Trans 3-[6-(1,3-Dimethyl-1H...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent