BDBM364459 (R or S)-2-fluoro-N-[6-(1- hydroxyethyl)-2-phenyl-2H- pyrazolo[4,3-b]pyridin-3-yl]-5-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide, isomer A::US9862707, Example 33::US9862707, Example 34

SMILES CC(O)c1cnc2c(NC(=O)c3cc(-c4ccn(C)n4)c(cc3F)C(F)(F)F)n(nc2c1)-c1ccccc1

InChI Key InChIKey=CDGQZCLRDVGCPS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 364459   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364459(US9862707, Example 33 | US9862707, Example 34 | (R...)
Affinity DataIC50: 0.25nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364459(US9862707, Example 33 | US9862707, Example 34 | (R...)
Affinity DataIC50: 0.480nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364459(US9862707, Example 33 | US9862707, Example 34 | (R...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed