BDBM364417 US9862688, Compound 4

SMILES Clc1cnc(Nc2ccc(cc2)N2CCN(CCCCNC(=O)CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)CC2)nc1NCc1cccc(NC(=O)C=C)c1

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 364417   

TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 7.95nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 64.8nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 252nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 415nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 372nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 623nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetUMP-CMP kinase(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364417(US9862688, Compound 4)
Affinity DataIC50: 3.80E+4nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent