BDBM364403 US9862688, Compound 2

SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(CCCNC(=O)CC2[C@H]3C[C@@H]4C[C@H](C[C@@H]2C4)C3)CC1

InChI Key

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 364403   

TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 45nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 382nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 3.35E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 3.11E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 1.82E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 3.04E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetZinc finger protein GLIS2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 1.93E+5nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
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TargetUMP-CMP kinase(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364403(US9862688, Compound 2)
Affinity DataIC50: 2.73E+5nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
Go to US Patent