BDBM363505 9-(3,5-Dimethylisoxazol-4-yl)-6-methoxy-3-pyridin-3-yl-2,3-dihydro[1,4]oxazino[2,3,4-hi]indazole::US9850257, Example 12

SMILES COc1nn2C(COc3c(ccc1c23)-c1c(C)noc1C)c1cccnc1

InChI Key InChIKey=YNBOGCWGWXPMEY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 363505   

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandPNGBDBM363505(US9850257, Example 12 | 9-(3,5-Dimethylisoxazol-4-...)
Affinity DataIC50: 200nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM363505(US9850257, Example 12 | 9-(3,5-Dimethylisoxazol-4-...)
Affinity DataIC50: 200nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent