BDBM363488 9-(2-hydroxy-2-(2-methyl-6-(1H- tetrazol-1-yl)pyridin-3-yl)ethyl)- 4-(4-methyl-5-oxo-2,5- dihydrofuran-3-yl)-1-oxa-4,9- diazaspiro[5.5]undecan-5-one::US9850245, Example 39

SMILES CC1=C(COC1=O)N1CCCOC2(CCN(CC(O)c3ccc(nc3C)-n3cnnn3)CC2)C1=O

InChI Key InChIKey=AEUAJUWFIUOPNZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363488   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363488(US9850245, Example 39 | 9-(2-hydroxy-2-(2-methyl-6...)
Affinity DataIC50: 13nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
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Date in BDB:
11/14/2019
Entry Details
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