BDBM363486 (R)-9-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroisobenzofuran-5- yl)ethyl)-1-methyl-4-(4-methyl- 5-oxo-2,5-dihydrofuran-3-yl)- 1,4,9-triazaspiro[5.5]undecan-5- one::US9850245, Example 34

SMILES CN1CCN(C2=C(C)C(=O)OC2)C(=O)C11CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1

InChI Key InChIKey=QTZRJXBMUKIHDH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363486   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363486(US9850245, Example 34 | (R)-9-(2-hydroxy-2-(4-meth...)
Affinity DataIC50: 27nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent