BDBM363482 (R)-5-(1-hydroxy-2-(4-(4-methyl- 5-oxo-2,5-dihydrofuran-3-yl)-1- oxa-4,9-diazaspiro[5.5]undecan- 9-yl)ethyl)-4- methylisobenzofuran-1(3H)-one::US9850245, Example 21

SMILES CC1=C(COC1=O)N1CCOC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1

InChI Key InChIKey=XZSCOTBCHJVTMN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363482   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363482(US9850245, Example 21 | (R)-5-(1-hydroxy-2-(4-(4-m...)
Affinity DataIC50: 77nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
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Date in BDB:
11/14/2019
Entry Details
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