BDBM363479 (S)-4-(9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hydroxyethyl)- 1-oxa-4,9- diazaspiro[5.5]undecan-4- yl)furan-2(5H)-one::US9850245, Example 19B

SMILES O[C@H](CN1CCC2(CC1)CN(CCO2)C1=CC(=O)OC1)c1ccc(nc1)-n1cnnn1

InChI Key InChIKey=ZDGQAXHZJFGWOU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363479   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363479(US9850245, Example 19B | (S)-4-(9-(2-(6-(1H-tetraz...)
Affinity DataIC50: 100nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
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Date in BDB:
11/14/2019
Entry Details
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