BDBM363477 9-(2-(5-(1H-tetrazol-1- yl)pyrazin-2-yl)-2- hydroxyethyl)-4-(4-methyl-5- oxo-2,5-dihydrofuran-3-yl)-1- oxa-4,9-diazaspiro[5.5]undecan- 5-one (single diastereomer, absolute stereochemistry not established)::US9850245, Example 18A

SMILES CC1=C(COC1=O)N1CCOC2(CCN(CC(O)c3cnc(cn3)-n3cnnn3)CC2)C1=O

InChI Key InChIKey=QLSDJMCUIHDWLF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363477   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363477(US9850245, Example 18A | 9-(2-(5-(1H-tetrazol-1- y...)
Affinity DataIC50: 12nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent