BDBM363476 (R)-8-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroisobenzofuran-5- yl)ethyl)-3-(5-oxo-2,5- dihydrofuran-3-yl)-1-oxa-3,8- diazaspiro[4.5]decan-2-one::US9850245, Example 16

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CN(C(=O)O2)C2=CC(=O)OC2)CC1

InChI Key InChIKey=YSVOUKRMJNOVCX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363476   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363476(US9850245, Example 16 | (R)-8-(2-hydroxy-2-(4-meth...)
Affinity DataIC50: 320nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent