BDBM363472 US9850245, Example 6A

SMILES CC1=C(COC1=O)N1CCOC2(CCN(C[C@@H](F)c3ccc(nc3)-n3cnnn3)CC2)C1=O

InChI Key InChIKey=OVFJHIJIDTWZPX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363472   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363472(US9850245, Example 6A)
Affinity DataIC50: 6.60nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
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