BDBM363380 (2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-(5-methyl-2-pyrazinyl)-2-butanesulfonamide::US9845310, Example 506.0

SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(C)c1

InChI Key InChIKey=DOMQFIFVDIAOOT-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 363380   

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM363380((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Affinity DataEC50:  1.20nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM363380((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed