BDBM363328 N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide::US9850225, Example 1247

SMILES CC(=O)NCCNCc1cc(Cl)c(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc1OCc1cccc(c1)C#N

InChI Key InChIKey=UYQDGSZLEYFTTB-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 363328   

TargetProgrammed cell death 1 ligand 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM363328(N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-...)
Affinity DataIC50: 5.30nMAssay Description:The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM363328(N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-...)
Affinity DataEC50: >3.30E+3nMAssay Description:Inhibition of PD-1/PD-L1 interaction in CHO cells expressing PD-Ll/TCR cocultured with human Jurkat cells expressing PD-1 assessed as activation of e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM363328(N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PD1 (unknown origin)/PDL1 (unknown origin) protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM363328(N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PD-1 binding to human PD-L1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed