BDBM363323 (R)-2-((5-chloro-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid::US9850225, Example 1242

SMILES OC[C@@H](NCc1cc(Cl)c(OCc2cccc(-c3ccc4OCCOc4c3)c2C#N)cc1OCc1cccc(c1)C#N)C(O)=O

InChI Key InChIKey=TWANQEJZCRZYJW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363323   

TargetProgrammed cell death 1 ligand 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM363323((R)-2-((5-chloro-4-((2-cyano-3-(2,3-dihydrobenzo[b...)
Affinity DataIC50: 5.30nMAssay Description:The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent