BDBM363065 (R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxypropanoic acid::US9850225, Example 1002

SMILES Cc1cc(OCc2cccc(c2C)-c2ccc3OCCOc3c2)cc(OCc2cccc(c2)C#N)c1CN[C@H](CO)C(O)=O

InChI Key InChIKey=YSYKQJKQKIDWAL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 363065   

TargetProgrammed cell death 1 ligand 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM363065(US9850225, Example 1002 | (R)-2-(2-(3-cyanobenzylo...)
Affinity DataIC50: 5.30nMAssay Description:The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM363065(US9850225, Example 1002 | (R)-2-(2-(3-cyanobenzylo...)
Affinity DataIC50: 48nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM363065(US9850225, Example 1002 | (R)-2-(2-(3-cyanobenzylo...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of C-terminal 3S-IG-tagged recombinant human PD-1 (25 to 167 residues)/C-terminal 6xHis-tagged recombinant human PD-L1 (18 to 239 residues...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed