BDBM362954 3-((6-Chloro-7-fluoro-1-(2-(3-(4-fluorobenzyl)pyrrolidin-1-yl)-2-oxoethyl)-2-methyl-1H-indol-3-yl)thio)benzoic acid ::US9850203, Compound 1-21::US9850203, Compound 1-65::US9850203, Compound 1-66

SMILES Cc1c(Sc2cccc(c2)C(O)=O)c2ccc(Cl)c(F)c2n1CC(=O)N1CCC(Cc2ccc(F)cc2)C1

InChI Key InChIKey=VJKZEULGIOPTGD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362954   

TargetAutotaxin(Human)
Pharmakea

US Patent
LigandPNGBDBM362954(US9850203, Compound 1-21 | US9850203, Compound 1-6...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Pharmakea

US Patent
LigandPNGBDBM362954(US9850203, Compound 1-21 | US9850203, Compound 1-6...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Pharmakea

US Patent
LigandPNGBDBM362954(US9850203, Compound 1-21 | US9850203, Compound 1-6...)
Affinity DataIC50: 1.75E+3nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent