BDBM362848 (R)-(4-chlorophenyl)(8- methyl-3-(5-methylfuran-2- yl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl)methanone::US9840508, Compound 10

SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1ccc(Cl)cc1

InChI Key InChIKey=QUXGPHXFLBRUBT-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 362848   

TargetNeuromedin-K receptor(Human)
Oged

US Patent
LigandPNGBDBM362848(US9840508, Compound 10 | (R)-(4-chlorophenyl)(8- m...)
Affinity DataIC50: 74nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
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TargetNeuromedin-K receptor(Human)
Oged

US Patent
LigandPNGBDBM362848(US9840508, Compound 10 | (R)-(4-chlorophenyl)(8- m...)
Affinity DataKi:  36nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetNeuromedin-K receptor(Human)
Oged

US Patent
LigandPNGBDBM362848(US9840508, Compound 10 | (R)-(4-chlorophenyl)(8- m...)
Affinity DataKi:  36nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetSubstance-K receptor(Human)
Oged

US Patent
LigandPNGBDBM362848(US9840508, Compound 10 | (R)-(4-chlorophenyl)(8- m...)
Affinity DataKi:  2.30E+4nMAssay Description:The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetSubstance-P receptor(Human)
Oged

US Patent
LigandPNGBDBM362848(US9840508, Compound 10 | (R)-(4-chlorophenyl)(8- m...)
Affinity DataKi:  2.50E+4nMAssay Description:The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent