BDBM362838 5-(trans-4-aminocyclohexyl)-N-butyl-8-((cyclopentylamino)methyl)-5,6-dihydropyrimido[4,5-c]isoquinolin-3-amine::US9840503, Example 11

SMILES CCCCNc1ncc2-c3ccc(CNC4CCCC4)cc3CN([C@H]3CC[C@H](N)CC3)c2n1

InChI Key InChIKey=DYVVCWFYAKHAJQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362838   

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM362838(US9840503, Example 11 | 5-(trans-4-aminocyclohexyl...)
Affinity DataIC50: 550nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM362838(US9840503, Example 11 | 5-(trans-4-aminocyclohexyl...)
Affinity DataIC50: 100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM362838(US9840503, Example 11 | 5-(trans-4-aminocyclohexyl...)
Affinity DataIC50: 100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent