BDBM362829 3-(Butylamino)-8-[(cyclohexylamino)methyl]-5-(trans-4-hydroxycyclohexyl)pyrimido[4,5-c]isoquinolin-6(5H)-one::US9840503, Example 2::US9840503, Example 6

SMILES CCCCNc1ncc2c3ccc(CNC4CCCCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1

InChI Key InChIKey=NUPBYEYIHGEJTM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 362829   

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM362829(US9840503, Example 2 | US9840503, Example 6 | 3-(B...)
Affinity DataIC50: 550nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM362829(US9840503, Example 2 | US9840503, Example 6 | 3-(B...)
Affinity DataIC50: 100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM362829(US9840503, Example 2 | US9840503, Example 6 | 3-(B...)
Affinity DataIC50: 100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM362829(US9840503, Example 2 | US9840503, Example 6 | 3-(B...)
Affinity DataIC50: 550nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM362829(US9840503, Example 2 | US9840503, Example 6 | 3-(B...)
Affinity DataIC50: 100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM362829(US9840503, Example 2 | US9840503, Example 6 | 3-(B...)
Affinity DataIC50: 100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details
Go to US Patent