BDBM362671 (4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4- (2,2-dimethylpropanoyl)piperazin-1-yl]-4- pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazine::US10227359, Example 26::US10618910, Example 26::US9834565, Example 26

SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN(CC3)C(=O)C(C)(C)C)n3[C@H](COc1c23)c1ccccn1

InChI Key InChIKey=CYANTQDGHUIJGZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 362671   

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM362671(US9834565, Example 26 | (4S)-7-(3,5-dimethylisoxaz...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandPNGBDBM362671(US9834565, Example 26 | (4S)-7-(3,5-dimethylisoxaz...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandPNGBDBM362671(US9834565, Example 26 | (4S)-7-(3,5-dimethylisoxaz...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandPNGBDBM362671(US9834565, Example 26 | (4S)-7-(3,5-dimethylisoxaz...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM362671(US9834565, Example 26 | (4S)-7-(3,5-dimethylisoxaz...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM362671(US9834565, Example 26 | (4S)-7-(3,5-dimethylisoxaz...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent