BDBM3625 3-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazolin-1-yl}propane-1,2-diol::5-[(3-bromophenyl)amino]-1-(2,3-dihydroxypropyl)pyrazolo[4,3-g]quinazoline::Pyrazoloquinazoline deriv. 2c

SMILES OCC(O)Cn1ncc2cc3c(Nc4cccc(Br)c4)ncnc3cc12

InChI Key InChIKey=YSBALMSOJQNWOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 3625   

TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM3625(3-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quin...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM3625(3-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quin...)
Affinity DataIC50: 316nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed