BDBM362426 4-{7-amino-3- [(6R,8aS)-3- oxooctahydroindolizin- 6-yl]-1H-pyrazolo[3,4-c] pyridin-1-yl}- 3-methoxy-N-[4- (trifluoromethyl)pyridin-2-yl] benzamide::US9834554, Example 40

SMILES COc1cc(ccc1-n1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)c2ccnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key InChIKey=WRBUMTNSBJPDOH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 362426   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362426(4-{7-amino-3- [(6R,8aS)-3- oxooctahydroindolizin- ...)
Affinity DataIC50: 1.10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
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