BDBM362423 US9834554, Example 37

SMILES COc1cc(ccc1-n1nc([C@@H]2CC[C@H](C)N(C2)C(=O)C2CC2)c2ccnc(N)c12)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=DTOBOKWPQAVHNX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 362423   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362423(US9834554, Example 37)
Affinity DataIC50: 2.10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent