BDBM362351 4-{7-amino-3-[(2R)-4- propanoylmorpholin-2- yl]-1H-pyrazolo[3,4-c] pyridin-1-yl}-N-[4- (trifluoromethyl)pyridin-2-yl] benzamide::US9834554, Example 3

SMILES CCC(=O)N1CCO[C@H](C1)c1nn(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccc12

InChI Key InChIKey=QZNAGSJHKRXROB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 362351   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362351(US9834554, Example 3 | 4-{7-amino-3-[(2R)-4- propa...)
Affinity DataIC50: 1.80nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent