BDBM362031 (S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-5-chloro-8-fluoro-4-oxoquinazolin-3(4H)-yl)benzamide::US10221197, Compound 24

SMILES C[C@H](Nc1nc(N)nc(C(F)F)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(c1)C(N)=O

InChI Key InChIKey=ZXFPBJYYMJNXTR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362031   

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362031((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50: 2.50E+4nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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LigandPNGBDBM362031((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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LigandPNGBDBM362031((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50: 6.60E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent