BDBM361407 (4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[d] isothiazol-3-yl) piperidin-1-yl) (cyclopropyl) methanone::US10221172, Example 71

SMILES O=C(C1CC1)N1CCC(CC1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=QIFRHKLNUQIHEG-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 361407   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361407((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Affinity DataEC50:  388nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361407((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Affinity DataEC50:  389nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361407((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Affinity DataEC50:  389nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed