BDBM361378 3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl) benzo[d]isothiazol- 6-amine::US10221172, Example 36

SMILES C1CC1c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=KORQLNIAJHVCSJ-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 361378   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361378(3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl)...)
Affinity DataEC50:  78.2nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM361378(3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl)...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361378(3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl)...)
Affinity DataEC50:  81nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361378(3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl)...)
Affinity DataEC50:  81nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed