BDBM361358 6-((1H-pyrazolo[4,3-b] pyridin-3- yl)amino)-N-(3,3- difluorocyclobutyl)-N- methylbenzo[d] isothiazole-3- carboxamide::US10221172, Example 15

SMILES CN(C1CC(F)(F)C1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=YFQMDJXCLJRRLV-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 361358   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361358(6-((1H-pyrazolo[4,3-b] pyridin-3- yl)amino)-N-(3,3...)
Affinity DataEC50:  164nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361358(6-((1H-pyrazolo[4,3-b] pyridin-3- yl)amino)-N-(3,3...)
Affinity DataEC50:  68nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361358(6-((1H-pyrazolo[4,3-b] pyridin-3- yl)amino)-N-(3,3...)
Affinity DataEC50:  68nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed