BDBM361318 (S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (aminomethyl)benzo[d]thiazol- 5-yl)-3-(2H-tetrazol-5- yl)benzene-1,2-disulfonamide::US10221163, Example 475::US10544130, Example 475

SMILES NC[C@@H](CO)NS(=O)(=O)c1ccc(-c2ccc3sc(CN)nc3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=XFHGATVLSRCKLK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361318   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.130nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.0600nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.0870nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.130nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.0870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent