BDBM361269 (S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-amino-3-hydroxypropan-2-yl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 426::US10544130, Example 426

SMILES NCC(CO)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O

InChI Key InChIKey=YZUWHIDXKAVWBK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361269   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361269((S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-ami...)
Affinity DataIC50: 0.0320nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361269((S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-ami...)
Affinity DataIC50: 0.0320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361269((S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-ami...)
Affinity DataIC50: 0.168nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361269((S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-ami...)
Affinity DataIC50: 0.168nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361269((S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-ami...)
Affinity DataIC50: 0.273nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361269((S)-4-(2-Amino-1H-benzo[d]imidazol-4-yl)-N1-(1-ami...)
Affinity DataIC50: 0.273nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent