BDBM361234 2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5- yl)phenyl]sulfonyl} amino)-N,N,N- trimethylethanaminium trifluoroacetate::US10221163, Example 391

SMILES C[N+](C)(C)CCNS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(=O)=O

InChI Key InChIKey=XXMMMNLRBCLZOO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 361234   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361234(2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamo...)
Affinity DataIC50: 0.0280nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361234(2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamo...)
Affinity DataIC50: 0.0970nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361234(2-({[4-(2-amino-1,3- benzothiazol-4-yl)-2- sulfamo...)
Affinity DataIC50: 0.209nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent