BDBM361042 N1-(2-aminoethyl)-4-(1H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 199::US10544130, Example 199

SMILES NCCNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=ABGWLUMGGAKQLX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361042   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.102nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.0260nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.0470nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.102nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.0260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.0470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent