BDBM360598 US9828369, Example 155::methyl 3-(8-((3-(2,3- dichlorophenyl)ureido)methyl)isoquinolin- 5-yl)benzoate

SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12

InChI Key InChIKey=ABURUAFJRDJWAN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 360598   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360598(methyl 3-(8-((3-(2,3- dichlorophenyl)ureido)methyl...)
Affinity DataIC50: 1.96E+3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM360598(methyl 3-(8-((3-(2,3- dichlorophenyl)ureido)methyl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MGAT2 (unknown origin) by CPM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360598(methyl 3-(8-((3-(2,3- dichlorophenyl)ureido)methyl...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed