BDBM360396 US9828368, Example 48::US9828368, Example 49

SMILES CC[C@@](C)(O)c1nc(oc1C)C1CC[C@@H](C)N(C1)C(=O)c1ccsc1-n1nccn1

InChI Key InChIKey=AFWTWXQYFDNUSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 360396   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360396(US9828368, Example 48 | US9828368, Example 49)
Affinity DataIC50: 15nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360396(US9828368, Example 48 | US9828368, Example 49)
Affinity DataIC50: 1.82E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360396(US9828368, Example 48 | US9828368, Example 49)
Affinity DataIC50: 16nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360396(US9828368, Example 48 | US9828368, Example 49)
Affinity DataIC50: 1.74E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent