BDBM360395 (4-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-5-(4-((R)-2-hydroxybutan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone::US9828368, Example 47

SMILES CC[C@@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cscc1-n1nccn1

InChI Key InChIKey=QIFHYQSASFBJSW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 360395   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360395(US9828368, Example 47 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 18nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360395(US9828368, Example 47 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 9.77E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent