BDBM359840 2-isopropyl-2-methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-7-(6-(piperazin-1-yl)pyridin-3-yl)-2,3-dihydrobenzofuran-5-carboxamide, 2 HCl::US9822103, Example 88

SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2CC(C)(Oc2c(c1)-c1ccc(nc1)N1CCNCC1)C(C)C

InChI Key InChIKey=RYMAWHSALLDJPO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359840   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM359840(2-isopropyl-2-methyl-N-((6-methyl-2-oxo-4-propyl-1...)
Affinity DataIC50: 500nMAssay Description:EZH2 Histone Methyl Transferase Assay: The effectiveness of compounds of the present invention as inhibitors of histone methyl transferases can be r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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