BDBM359755 N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(6-methoxypyridin-3-yl)-2,2,4-trimethyl-2,3-dihydrobenzofuran-5-carboxamide::US9822103, Example 25

SMILES COc1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c(C)c2CC(C)(C)Oc12

InChI Key InChIKey=AWJFCBJCUFPJAZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359755   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM359755(N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 750nMAssay Description:EZH2 Histone Methyl Transferase Assay: The effectiveness of compounds of the present invention as inhibitors of histone methyl transferases can be r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent