BDBM359689 N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({6-[isopropyl(methyl)amino]pyridin-3-yl}methyl)pyridine-3-carboxamide::US10221161, Example 73::US11242333, Example 73

SMILES CC(C)N(C)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1

InChI Key InChIKey=QHAUWEJXKZUUPP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 359689   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359689(US10221161, Example 73 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 51.1nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359689(US10221161, Example 73 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 6.69E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359689(US10221161, Example 73 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 6.69E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM359689(US10221161, Example 73 | N-[(1-Aminoisoquinolin-6-...)
Affinity DataIC50: 51.1nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent